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The present study simvastatin have important effect on element metobolism especially zinc, copper, iron, potassium during sepsis. Results: The levels of zinc, iron, potassium and copper were found increased in the simvastatin+LPS group compared with LPS group (p<0.05). In the simvastatin+LPS group, levels of calcium and sodium were lower than those of LPS and controls (p<0.05 and p<0.01, respectively). The IL-10 levels was found higher in simvastatin+LPS group compared to LPS group (p<0.01). Serum and tissue TNF-α and IL-10 levels were higher in the simvastatin+LPS and LPS groups (p<0.05). This study measured serum and tissue levels of Tumor Necrosis Factor-α (TNF-α), interleukin-10 (IL-10) using ELISA. Selenium, zinc, iron, manganese, magnesium, calcium, sodium, copper and potassium element levels in intestinal tissue were analyzed by inductively coupled plasma-optical emission spectroscopy (icp-oes). Methodology: Rats were divided into four groups: control, lipopolysaccharide (LPS) (20 mg kg -1, i.p.), simvastatin (20 mg kg -1, p.o.) and the simvastatin+LPS group. Aim: This study aimed to observe the effect of prior treatment with simvastatin on elements in intestinal tissue of rats during the early-phase of sepsis. But it is not clear simvastatin on element levels and its mechanism. There are a lot of studies shown that simvastatin possess potent anti-inflammation and antioxidation capacity.
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Intestine is main organ for absorption of element. As a consequence, Micro Snitch may show a device as inactive even while it is used in certain professional audio/video software. The changes of micro and macro element levels plays important roles normal physiologic states and pathological states especially inflammation. In Intestinal Tissue for During Early Phase of SepsisĪbstract: Background: There are limited studies in the literature micro and macro elements of level during early phase of sepsis. Investigation of Simvastatin on Micro and Macro Element Levels
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